Contact: alinat2@uci.edu
Last Updated: 6/1/2024
About: This script is the structural analysis of the Maze Learning
Individual Differences (MLINDIV) project, specifically looking at young
adult hippocampal subfield volumes/ thicknesses and their relationship
with navigation ability.

Total Volumes + Propcorrect or Patheff (n=99)
## [1] "propcorrect"
## r p-value
## LHC 0.135 0.02032
## RHC 0.133 0.02258
## totalHC 0.138 0.01713
## [1] "patheff_acc_only"
## r p-value
## LHC -0.017 0.76534
## RHC 0.007 0.90947
## totalHC -0.006 0.91827
raw pval, bonferroni pval, BH pval
## pc_raw_p pc_bonf_p pc_BH_p pe_acc_raw_p pe_acc_bonf_p pe_acc_BH_p
## LHC 0.02032 0.04064 0.02258 0.76534 1 0.90947
## RHC 0.02258 0.04516 0.02258 0.90947 1 0.90947
propcorrect
Females (n=46)
## [1] "propcorrect"
## r p-value
## LHC -0.206 0.04999
## RHC -0.289 0.00545
## totalHC -0.256 0.01432
## [1] "patheff_acc_only"
## r p-value
## LHC 0.115 0.27712
## RHC 0.171 0.10516
## totalHC 0.148 0.16266
Males (n=53)
## [1] "propcorrect"
## r p-value
## LHC -0.129 0.19092
## RHC -0.130 0.18740
## totalHC -0.137 0.16463
## [1] "patheff_acc_only"
## r p-value
## LHC 0.118 0.22974
## RHC 0.153 0.11839
## totalHC 0.143 0.14532
raw pval, bonferroni pval, BH pval
## pc_raw_p pc_bonf_p pc_BH_p pe_acc_raw_p pe_acc_bonf_p pe_acc_BH_p
## LHC_f 0.04999 0.09998 0.04999 0.27712 0.55424 0.27712
## RHC_f 0.00545 0.01090 0.01090 0.10516 0.21032 0.21032
## LHC_m 0.19092 0.38184 0.19092 0.22974 0.45948 0.22974
## RHC_m 0.18740 0.37480 0.19092 0.11839 0.23678 0.22974
Total Thickness + Propcorr or Patheff (n=98)
## [1] "propcorrect"
## r p-value
## tLHC 0.100 0.08746
## tRHC -0.009 0.88058
## [1] "patheff_acc_only"
## r p-value
## tLHC -0.025 0.66457
## tRHC 0.051 0.38832
raw pval, bonferroni pval, BH pval
## pc_raw_p pc_bonf_p pc_BH_p pe_acc_raw_p pe_acc_bonf_p pe_acc_BH_p
## LHC 0.08746 0.17492 0.17492 0.66457 1.00000 0.66457
## RHC 0.88058 1.00000 0.88058 0.38832 0.77664 0.66457
Females (n=46)
## [1] "propcorrect"
## r p-value
## tLHC -0.089 0.403
## tRHC -0.272 0.009
## [1] "patheff_acc_only"
## r p-value
## tLHC 0.091 0.38837
## tRHC 0.171 0.10473
Males (n=52)
## [1] "propcorrect"
## r p-value
## tLHC -0.056 0.57615
## tRHC -0.077 0.43789
## [1] "patheff_acc_only"
## r p-value
## tLHC 0.022 0.82464
## tRHC 0.074 0.45695
raw pval, bonferroni pval, BH pval
## pc_raw_p pc_bonf_p pc_BH_p pe_acc_raw_p pe_acc_bonf_p pe_acc_BH_p
## LHC_f 0.40300 0.80600 0.40300 0.38837 0.77674 0.38837
## RHC_f 0.00900 0.01800 0.01800 0.10473 0.20946 0.20946
## LHC_m 0.57615 1.00000 0.57615 0.82464 1.00000 0.82464
## RHC_m 0.43789 0.87578 0.57615 0.45695 0.91390 0.82464
propcorrect

Bilateral Ant/Post Volumes + Propcorr or Patheff (n=99)
## [1] "propcorrect"
## r p-value
## LaHC 0.193 0.00083
## LpHC -0.063 0.27750
## RaHC 0.213 0.00022
## RpHC -0.077 0.18827
## [1] "patheff_acc_only"
## r p-value
## LaHC 0.035 0.54517
## LpHC -0.085 0.14426
## RaHC 0.050 0.39503
## RpHC -0.055 0.34823
raw pval, bonferroni pval, BH pval
## pc_raw_p pc_bonf_p pc_BH_p pe_acc_raw_p pe_acc_bonf_p pe_acc_BH_p
## LHC 0.08746 0.17492 0.17492 0.66457 1.00000 0.66457
## RHC 0.88058 1.00000 0.88058 0.38832 0.77664 0.66457
propcorrect


Females (n=46)
## [1] "propcorrect"
## r p-value
## LaHC 0.015 0.89066
## LpHC -0.309 0.00285
## RaHC -0.002 0.98539
## RpHC -0.331 0.00133
## [1] "patheff_acc_only"
## r p-value
## LaHC 0.212 0.04360
## LpHC -0.112 0.29070
## RaHC 0.313 0.00254
## RpHC -0.112 0.28841
Males (n=53)
## [1] "propcorrect"
## r p-value
## LaHC -0.189 0.05318
## LpHC 0.044 0.65540
## RaHC -0.094 0.33987
## RpHC -0.061 0.53639
## [1] "patheff_acc_only"
## r p-value
## LaHC 0.167 0.08838
## LpHC -0.032 0.74676
## RaHC 0.118 0.23210
## RpHC 0.064 0.51395
raw pval, bonferroni pval, BH pval
## pc_raw_p pc_bonf_p pc_BH_p pe_acc_raw_p pe_acc_bonf_p pe_acc_BH_p
## LaHC_f 0.89066 1.00000 0.89066 0.04360 0.17440 0.08720
## LpHC_f 0.00285 0.01140 0.00570 0.29070 1.00000 0.29070
## RaHC_f 0.89066 1.00000 0.89066 0.04360 0.17440 0.08720
## RpHC_f 0.00285 0.01140 0.00570 0.29070 1.00000 0.29070
## LaHC_m 0.05318 0.21272 0.10636 0.08838 0.35352 0.17676
## LpHC_m 0.65540 1.00000 0.65540 0.74676 1.00000 0.74676
## RaHC_m 0.05318 0.21272 0.10636 0.08838 0.35352 0.17676
## RpHC_m 0.65540 1.00000 0.65540 0.74676 1.00000 0.74676
Bilateral Ant/Post Thickness + Propcorr or Patheff (n=98)
## [1] "propcorrect"
## r p-value
## tLaHC 0.187 0.00132
## tLpHC -0.060 0.30650
## tRaHC 0.054 0.36083
## tRpHC -0.115 0.04880
## [1] "patheff_acc_only"
## r p-value
## tLaHC -0.018 0.75559
## tLpHC -0.071 0.22841
## tRaHC 0.082 0.16392
## tRpHC -0.003 0.95370
propcorrect

Females (n=46)
## [1] "propcorrect"
## r p-value
## tLaHC 0.114 0.28367
## tLpHC -0.306 0.00315
## tRaHC 0.066 0.53329
## tRpHC -0.402 0.00008
## [1] "patheff_acc_only"
## r p-value
## tLaHC 0.011 0.91590
## tLpHC 0.035 0.73942
## tRaHC 0.185 0.07987
## tRpHC 0.022 0.83958
Males (n=52)
## [1] "propcorrect"
## r p-value
## tLaHC -0.082 0.40912
## tLpHC 0.032 0.75157
## tRaHC -0.081 0.41870
## tRpHC -0.046 0.64307
## [1] "patheff_acc_only"
## r p-value
## tLaHC 0.137 0.16763
## tLpHC -0.128 0.19898
## tRaHC 0.073 0.46596
## tRpHC 0.051 0.60892
raw pval, bonferroni pval, BH pval
## pc_raw_p pc_bonf_p pc_BH_p pe_acc_raw_p pe_acc_bonf_p pe_acc_BH_p
## LaHC_f 0.28367 1.0000 0.28367 0.91590 1.00000 0.91590
## LpHC_f 0.00315 0.0126 0.00630 0.73942 1.00000 0.91590
## RaHC_f 0.28367 1.0000 0.28367 0.91590 1.00000 0.91590
## RpHC_f 0.00315 0.0126 0.00630 0.73942 1.00000 0.91590
## LaHC_m 0.40912 1.0000 0.75157 0.16763 0.67052 0.19898
## LpHC_m 0.75157 1.0000 0.75157 0.19898 0.79592 0.19898
## RaHC_m 0.40912 1.0000 0.75157 0.16763 0.67052 0.19898
## RpHC_m 0.75157 1.0000 0.75157 0.19898 0.79592 0.19898
L/R/Mean Post/Ant Ratio + Propcorr or Patheff (n=96)
## [1] "propcorrect"
## r p-value
## Lpa_ratio -0.164 0.00536
## Rpa_ratio -0.264 0.00001
## meanpa_ratio -0.231 0.00008
## [1] "patheff_acc_only"
## r p-value
## Lpa_ratio -0.071 0.22736
## Rpa_ratio -0.034 0.56116
## meanpa_ratio -0.060 0.30951
No cut-off HR-T2 Subfield Volumes + Propcorr or Patheff
(n=14)

propcorrect
|
|
(Left) r
|
(Left) p
|
(Left) p_bonf
|
(Left) p_BH
|
(Right) r
|
(Right) p
|
(Right) p_bonf
|
(Right) p_BH
|
|
CA1
|
0.32
|
0.0402
|
0.5628
|
0.2742
|
0.25
|
0.1137
|
1.0000
|
0.2742
|
|
CA2/3
|
0.37
|
0.0189
|
0.2646
|
0.2646
|
-0.26
|
0.1060
|
1.0000
|
0.2742
|
|
DG
|
0.07
|
0.6506
|
1.0000
|
0.8280
|
0.27
|
0.0839
|
1.0000
|
0.2742
|
|
SUB
|
-0.22
|
0.1709
|
1.0000
|
0.3418
|
-0.01
|
0.9733
|
1.0000
|
0.9733
|
|
ERC
|
-0.11
|
0.5033
|
1.0000
|
0.7046
|
-0.06
|
0.7317
|
1.0000
|
0.8536
|
|
PRC
|
0.13
|
0.4358
|
1.0000
|
0.6779
|
-0.19
|
0.2426
|
1.0000
|
0.4246
|
|
PHC
|
-0.04
|
0.8022
|
1.0000
|
0.8639
|
-0.25
|
0.1175
|
1.0000
|
0.2742
|
patheff (correct trials)
|
|
(Left) r
|
(Left) p
|
(Left) p_bonf
|
(Left) p_BH
|
(Right) r
|
(Right) p
|
(Right) p_bonf
|
(Right) p_BH
|
|
CA1
|
0.39
|
0.0108
|
0.1512
|
0.0504
|
0.42
|
0.0061
|
0.0854
|
0.0427
|
|
CA2/3
|
0.47
|
0.0020
|
0.0280
|
0.0280
|
0.28
|
0.0710
|
0.9940
|
0.1321
|
|
DG
|
0.28
|
0.0755
|
1.0000
|
0.1321
|
0.12
|
0.4531
|
1.0000
|
0.5767
|
|
SUB
|
0.17
|
0.2764
|
1.0000
|
0.3870
|
0.26
|
0.0957
|
1.0000
|
0.1489
|
|
ERC
|
0.10
|
0.5198
|
1.0000
|
0.5769
|
0.34
|
0.0308
|
0.4312
|
0.1078
|
|
PRC
|
-0.10
|
0.5357
|
1.0000
|
0.5769
|
0.01
|
0.9356
|
1.0000
|
0.9356
|
|
PHC
|
-0.29
|
0.0692
|
0.9688
|
0.1321
|
-0.31
|
0.0466
|
0.6524
|
0.1305
|
propcorrect


patheff (correct trials)

Females and Males
Females (n=6)
## [1] "propcorrect"
## (Left) r p-value (Right) r p-value
## CA1 -0.150 0.66044 0.212 0.53194
## CA2/3 0.247 0.46348 -0.320 0.33716
## DG -0.370 0.26314 -0.215 0.52465
## SUB -0.029 0.93277 0.568 0.06809
## ERC -0.292 0.38353 -0.446 0.16897
## PRC -0.312 0.34984 -0.632 0.03679
## PHC -0.503 0.11508 -0.816 0.00220
## [1] "patheff_acc_only"
## (Left) r p-value (Right) r p-value
## CA1 0.234 0.48944 0.695 0.01771
## CA2/3 0.856 0.00078 0.103 0.76347
## DG -0.025 0.94208 0.329 0.32247
## SUB -0.173 0.61025 -0.094 0.78249
## ERC 0.102 0.76615 0.605 0.04858
## PRC -0.228 0.50102 0.067 0.84478
## PHC -0.845 0.00106 -0.255 0.44834
No cut-off HR-T2 Subfield Thickness + Propcorr or Patheff
(n=26)
propcorrect
|
|
(Left) r
|
(Left) p
|
(Left) p_bonf
|
(Left) p_BH
|
(Right) r
|
(Right) p
|
(Right) p_bonf
|
(Right) p_BH
|
|
CA1
|
0.01
|
0.9483
|
1.0000
|
0.9483
|
-0.04
|
0.7198
|
1.0000
|
0.8999
|
|
CA2/3
|
0.16
|
0.1760
|
1.0000
|
0.8213
|
-0.03
|
0.8280
|
1.0000
|
0.8999
|
|
DG
|
0.24
|
0.0385
|
0.5390
|
0.5390
|
0.16
|
0.1536
|
1.0000
|
0.8213
|
|
SUB
|
-0.06
|
0.6116
|
1.0000
|
0.8999
|
-0.03
|
0.8246
|
1.0000
|
0.8999
|
|
ERC
|
0.05
|
0.6856
|
1.0000
|
0.8999
|
0.08
|
0.4649
|
1.0000
|
0.8999
|
|
PRC
|
-0.08
|
0.4890
|
1.0000
|
0.8999
|
0.08
|
0.5167
|
1.0000
|
0.8999
|
|
PHC
|
0.08
|
0.4925
|
1.0000
|
0.8999
|
-0.02
|
0.8356
|
1.0000
|
0.8999
|
patheff (correct trials)
|
|
(Left) r
|
(Left) p
|
(Left) p_bonf
|
(Left) p_BH
|
(Right) r
|
(Right) p
|
(Right) p_bonf
|
(Right) p_BH
|
|
CA1
|
-0.08
|
0.4631
|
1.0000
|
0.6608
|
-0.01
|
0.9596
|
1.0000
|
0.9596
|
|
CA2/3
|
0.23
|
0.0434
|
0.6076
|
0.1519
|
0.11
|
0.3567
|
1.0000
|
0.6242
|
|
DG
|
-0.16
|
0.1701
|
1.0000
|
0.3969
|
-0.02
|
0.8953
|
1.0000
|
0.9596
|
|
SUB
|
0.07
|
0.5192
|
1.0000
|
0.6608
|
0.11
|
0.3303
|
1.0000
|
0.6242
|
|
ERC
|
-0.27
|
0.0193
|
0.2702
|
0.1351
|
-0.20
|
0.0890
|
1.0000
|
0.2492
|
|
PRC
|
0.32
|
0.0046
|
0.0644
|
0.0644
|
-0.08
|
0.5111
|
1.0000
|
0.6608
|
|
PHC
|
-0.06
|
0.5800
|
1.0000
|
0.6767
|
-0.25
|
0.0314
|
0.4396
|
0.1465
|

Females and Males
Females (n=13)
## [1] "propcorrect"
## (Left) r p-value (Right) r p-value
## CA1 -0.410 0.04177 -0.458 0.02126
## CA2/3 0.042 0.84191 0.042 0.84106
## DG 0.352 0.08459 -0.044 0.83305
## SUB -0.136 0.51586 -0.280 0.17558
## ERC 0.017 0.93708 -0.100 0.63391
## PRC -0.080 0.70364 -0.199 0.33931
## PHC 0.055 0.79570 -0.380 0.06085
## [1] "patheff_acc_only"
## (Left) r p-value (Right) r p-value
## CA1 0.133 0.52739 0.205 0.32540
## CA2/3 0.393 0.05201 0.009 0.96566
## DG -0.468 0.01828 0.140 0.50312
## SUB 0.146 0.48544 0.187 0.37103
## ERC -0.439 0.02807 -0.184 0.37928
## PRC 0.476 0.01627 0.414 0.03985
## PHC 0.098 0.64117 -0.184 0.37865
Males (n=13)
## [1] "propcorrect"
## (Left) r p-value (Right) r p-value
## CA1 0.200 0.33764 0.036 0.86298
## CA2/3 -0.201 0.33610 -0.379 0.06159
## DG -0.243 0.24180 0.002 0.99338
## SUB -0.183 0.38116 -0.045 0.83076
## ERC -0.083 0.69331 0.220 0.28990
## PRC -0.320 0.11915 0.019 0.92804
## PHC 0.029 0.88983 0.224 0.28256
## [1] "patheff_acc_only"
## (Left) r p-value (Right) r p-value
## CA1 -0.256 0.21749 -0.222 0.28616
## CA2/3 0.194 0.35169 0.210 0.31342
## DG 0.171 0.41515 -0.128 0.54339
## SUB -0.003 0.98745 0.062 0.76776
## ERC -0.135 0.51852 -0.203 0.33057
## PRC 0.023 0.91246 -0.334 0.10316
## PHC -0.181 0.38556 -0.303 0.14064
HR-T2 Body-only Subfield Volumes + Propcorr or Patheff
(n=17)
[Not analyzed in manuscript]
HR-T2 Body-only Subfield Thickness + Propcorr or Patheff
(n=17)
[Not analyzed in manuscript]
Full Reg-T2 Subfield Volumes + Propcorr or Patheff (n=26)
propcorrect
|
|
(Left) r
|
(Left) p
|
(Left) p_bonf
|
(Left) p_BH
|
(Right) r
|
(Right) p
|
(Right) p_bonf
|
(Right) p_BH
|
|
aHC
|
0.24
|
0.0388
|
0.3880
|
0.3880
|
0.04
|
0.7331
|
1.0000
|
0.8146
|
|
pHC
|
0.02
|
0.8751
|
1.0000
|
0.8751
|
0.10
|
0.3942
|
1.0000
|
0.7195
|
|
ERC
|
-0.11
|
0.3378
|
1.0000
|
0.7195
|
-0.07
|
0.5195
|
1.0000
|
0.7195
|
|
PRC
|
-0.06
|
0.5756
|
1.0000
|
0.7195
|
-0.16
|
0.1764
|
1.0000
|
0.5880
|
|
PHC
|
-0.07
|
0.5346
|
1.0000
|
0.7195
|
0.18
|
0.1140
|
1.0000
|
0.5700
|
patheff (correct trials)
|
|
(Left) r
|
(Left) p
|
(Left) p_bonf
|
(Left) p_BH
|
(Right) r
|
(Right) p
|
(Right) p_bonf
|
(Right) p_BH
|
|
aHC
|
0.17
|
0.1316
|
1.0000
|
0.2193
|
0.19
|
0.0913
|
0.9130
|
0.1836
|
|
pHC
|
-0.12
|
0.3053
|
1.0000
|
0.3392
|
0.07
|
0.5635
|
1.0000
|
0.5635
|
|
ERC
|
-0.14
|
0.2316
|
1.0000
|
0.2895
|
-0.37
|
0.0010
|
0.0100
|
0.0100
|
|
PRC
|
0.14
|
0.2180
|
1.0000
|
0.2895
|
0.19
|
0.0918
|
0.9180
|
0.1836
|
|
PHC
|
-0.33
|
0.0035
|
0.0350
|
0.0175
|
-0.27
|
0.0163
|
0.1630
|
0.0543
|
patheff (correct trials)


Full Reg-T2 Subfield Thickness + Propcorr or Patheff (n=26)
propcorrect
|
|
(Left) r
|
(Left) p
|
(Left) p_bonf
|
(Left) p_BH
|
(Right) r
|
(Right) p
|
(Right) p_bonf
|
(Right) p_BH
|
|
aHC
|
0.05
|
0.6568
|
1.0000
|
0.8313
|
-0.02
|
0.8313
|
1.0000
|
0.8313
|
|
pHC
|
-0.08
|
0.4931
|
1.0000
|
0.8313
|
-0.03
|
0.7835
|
1.0000
|
0.8313
|
|
ERC
|
-0.12
|
0.3169
|
1.0000
|
0.8313
|
-0.08
|
0.4968
|
1.0000
|
0.8313
|
|
PRC
|
-0.03
|
0.7839
|
1.0000
|
0.8313
|
-0.19
|
0.0951
|
0.9510
|
0.4755
|
|
PHC
|
-0.27
|
0.0158
|
0.1580
|
0.1580
|
-0.03
|
0.7863
|
1.0000
|
0.8313
|
patheff (correct trials)
|
|
(Left) r
|
(Left) p
|
(Left) p_bonf
|
(Left) p_BH
|
(Right) r
|
(Right) p
|
(Right) p_bonf
|
(Right) p_BH
|
|
aHC
|
0.18
|
0.1204
|
1.0000
|
0.2361
|
0.23
|
0.0428
|
0.4280
|
0.2140
|
|
pHC
|
0.06
|
0.5843
|
1.0000
|
0.5843
|
0.16
|
0.1653
|
1.0000
|
0.2361
|
|
ERC
|
-0.17
|
0.1478
|
1.0000
|
0.2361
|
-0.37
|
0.0008
|
0.0080
|
0.0080
|
|
PRC
|
-0.14
|
0.2352
|
1.0000
|
0.2940
|
0.09
|
0.4407
|
1.0000
|
0.4897
|
|
PHC
|
-0.17
|
0.1462
|
1.0000
|
0.2361
|
-0.20
|
0.0837
|
0.8370
|
0.2361
|
patheff (correct trials)
