MLINDIV Structural Analysis A: Maze DVs

Contact: alinat2@uci.edu

Last Updated: 6/1/2024

About: This script is the structural analysis of the Maze Learning Individual Differences (MLINDIV) project, specifically looking at young adult hippocampal subfield volumes/ thicknesses and their relationship with navigation ability.

Total Volumes + Propcorrect or Patheff (n=99)

## [1] "propcorrect"
##             r p-value
## LHC     0.135 0.02032
## RHC     0.133 0.02258
## totalHC 0.138 0.01713
## [1] "patheff_acc_only"
##              r p-value
## LHC     -0.017 0.76534
## RHC      0.007 0.90947
## totalHC -0.006 0.91827

raw pval, bonferroni pval, BH pval

##     pc_raw_p pc_bonf_p pc_BH_p pe_acc_raw_p pe_acc_bonf_p pe_acc_BH_p
## LHC  0.02032   0.04064 0.02258      0.76534             1     0.90947
## RHC  0.02258   0.04516 0.02258      0.90947             1     0.90947

propcorrect

Females (n=46)

## [1] "propcorrect"
##              r p-value
## LHC     -0.206 0.04999
## RHC     -0.289 0.00545
## totalHC -0.256 0.01432
## [1] "patheff_acc_only"
##             r p-value
## LHC     0.115 0.27712
## RHC     0.171 0.10516
## totalHC 0.148 0.16266

Males (n=53)

## [1] "propcorrect"
##              r p-value
## LHC     -0.129 0.19092
## RHC     -0.130 0.18740
## totalHC -0.137 0.16463
## [1] "patheff_acc_only"
##             r p-value
## LHC     0.118 0.22974
## RHC     0.153 0.11839
## totalHC 0.143 0.14532

raw pval, bonferroni pval, BH pval

##       pc_raw_p pc_bonf_p pc_BH_p pe_acc_raw_p pe_acc_bonf_p pe_acc_BH_p
## LHC_f  0.04999   0.09998 0.04999      0.27712       0.55424     0.27712
## RHC_f  0.00545   0.01090 0.01090      0.10516       0.21032     0.21032
## LHC_m  0.19092   0.38184 0.19092      0.22974       0.45948     0.22974
## RHC_m  0.18740   0.37480 0.19092      0.11839       0.23678     0.22974

propcorrect

Total Thickness + Propcorr or Patheff (n=98)

## [1] "propcorrect"
##           r p-value
## tLHC  0.100 0.08746
## tRHC -0.009 0.88058
## [1] "patheff_acc_only"
##           r p-value
## tLHC -0.025 0.66457
## tRHC  0.051 0.38832

raw pval, bonferroni pval, BH pval

##     pc_raw_p pc_bonf_p pc_BH_p pe_acc_raw_p pe_acc_bonf_p pe_acc_BH_p
## LHC  0.08746   0.17492 0.17492      0.66457       1.00000     0.66457
## RHC  0.88058   1.00000 0.88058      0.38832       0.77664     0.66457

Females (n=46)

## [1] "propcorrect"
##           r p-value
## tLHC -0.089   0.403
## tRHC -0.272   0.009
## [1] "patheff_acc_only"
##          r p-value
## tLHC 0.091 0.38837
## tRHC 0.171 0.10473

Males (n=52)

## [1] "propcorrect"
##           r p-value
## tLHC -0.056 0.57615
## tRHC -0.077 0.43789
## [1] "patheff_acc_only"
##          r p-value
## tLHC 0.022 0.82464
## tRHC 0.074 0.45695

raw pval, bonferroni pval, BH pval

##       pc_raw_p pc_bonf_p pc_BH_p pe_acc_raw_p pe_acc_bonf_p pe_acc_BH_p
## LHC_f  0.40300   0.80600 0.40300      0.38837       0.77674     0.38837
## RHC_f  0.00900   0.01800 0.01800      0.10473       0.20946     0.20946
## LHC_m  0.57615   1.00000 0.57615      0.82464       1.00000     0.82464
## RHC_m  0.43789   0.87578 0.57615      0.45695       0.91390     0.82464

propcorrect

Bilateral Ant/Post Volumes + Propcorr or Patheff (n=99)

## [1] "propcorrect"
##           r p-value
## LaHC  0.193 0.00083
## LpHC -0.063 0.27750
## RaHC  0.213 0.00022
## RpHC -0.077 0.18827
## [1] "patheff_acc_only"
##           r p-value
## LaHC  0.035 0.54517
## LpHC -0.085 0.14426
## RaHC  0.050 0.39503
## RpHC -0.055 0.34823

raw pval, bonferroni pval, BH pval

##     pc_raw_p pc_bonf_p pc_BH_p pe_acc_raw_p pe_acc_bonf_p pe_acc_BH_p
## LHC  0.08746   0.17492 0.17492      0.66457       1.00000     0.66457
## RHC  0.88058   1.00000 0.88058      0.38832       0.77664     0.66457

propcorrect

Females (n=46)

## [1] "propcorrect"
##           r p-value
## LaHC  0.015 0.89066
## LpHC -0.309 0.00285
## RaHC -0.002 0.98539
## RpHC -0.331 0.00133
## [1] "patheff_acc_only"
##           r p-value
## LaHC  0.212 0.04360
## LpHC -0.112 0.29070
## RaHC  0.313 0.00254
## RpHC -0.112 0.28841

Males (n=53)

## [1] "propcorrect"
##           r p-value
## LaHC -0.189 0.05318
## LpHC  0.044 0.65540
## RaHC -0.094 0.33987
## RpHC -0.061 0.53639
## [1] "patheff_acc_only"
##           r p-value
## LaHC  0.167 0.08838
## LpHC -0.032 0.74676
## RaHC  0.118 0.23210
## RpHC  0.064 0.51395

raw pval, bonferroni pval, BH pval

##        pc_raw_p pc_bonf_p pc_BH_p pe_acc_raw_p pe_acc_bonf_p pe_acc_BH_p
## LaHC_f  0.89066   1.00000 0.89066      0.04360       0.17440     0.08720
## LpHC_f  0.00285   0.01140 0.00570      0.29070       1.00000     0.29070
## RaHC_f  0.89066   1.00000 0.89066      0.04360       0.17440     0.08720
## RpHC_f  0.00285   0.01140 0.00570      0.29070       1.00000     0.29070
## LaHC_m  0.05318   0.21272 0.10636      0.08838       0.35352     0.17676
## LpHC_m  0.65540   1.00000 0.65540      0.74676       1.00000     0.74676
## RaHC_m  0.05318   0.21272 0.10636      0.08838       0.35352     0.17676
## RpHC_m  0.65540   1.00000 0.65540      0.74676       1.00000     0.74676

propcorrect

patheff (correct trials)

Bilateral Ant/Post Thickness + Propcorr or Patheff (n=98)

## [1] "propcorrect"
##            r p-value
## tLaHC  0.187 0.00132
## tLpHC -0.060 0.30650
## tRaHC  0.054 0.36083
## tRpHC -0.115 0.04880
## [1] "patheff_acc_only"
##            r p-value
## tLaHC -0.018 0.75559
## tLpHC -0.071 0.22841
## tRaHC  0.082 0.16392
## tRpHC -0.003 0.95370

propcorrect

Females (n=46)

## [1] "propcorrect"
##            r p-value
## tLaHC  0.114 0.28367
## tLpHC -0.306 0.00315
## tRaHC  0.066 0.53329
## tRpHC -0.402 0.00008
## [1] "patheff_acc_only"
##           r p-value
## tLaHC 0.011 0.91590
## tLpHC 0.035 0.73942
## tRaHC 0.185 0.07987
## tRpHC 0.022 0.83958

Males (n=52)

## [1] "propcorrect"
##            r p-value
## tLaHC -0.082 0.40912
## tLpHC  0.032 0.75157
## tRaHC -0.081 0.41870
## tRpHC -0.046 0.64307
## [1] "patheff_acc_only"
##            r p-value
## tLaHC  0.137 0.16763
## tLpHC -0.128 0.19898
## tRaHC  0.073 0.46596
## tRpHC  0.051 0.60892

raw pval, bonferroni pval, BH pval

##        pc_raw_p pc_bonf_p pc_BH_p pe_acc_raw_p pe_acc_bonf_p pe_acc_BH_p
## LaHC_f  0.28367    1.0000 0.28367      0.91590       1.00000     0.91590
## LpHC_f  0.00315    0.0126 0.00630      0.73942       1.00000     0.91590
## RaHC_f  0.28367    1.0000 0.28367      0.91590       1.00000     0.91590
## RpHC_f  0.00315    0.0126 0.00630      0.73942       1.00000     0.91590
## LaHC_m  0.40912    1.0000 0.75157      0.16763       0.67052     0.19898
## LpHC_m  0.75157    1.0000 0.75157      0.19898       0.79592     0.19898
## RaHC_m  0.40912    1.0000 0.75157      0.16763       0.67052     0.19898
## RpHC_m  0.75157    1.0000 0.75157      0.19898       0.79592     0.19898

propcorrect

Total Ant/Post Volumes + Propcorr or Patheff (n=99)

## [1] "propcorrect"
##          r p-value
## aHC  0.219 0.00015
## pHC -0.076 0.19304
## [1] "patheff_acc_only"
##          r p-value
## aHC  0.045 0.43630
## pHC -0.075 0.19869

propcorrect

Females (n=46)

## [1] "propcorrect"
##          r p-value
## aHC  0.008 0.94234
## pHC -0.337 0.00109
## [1] "patheff_acc_only"
##          r p-value
## aHC  0.274 0.00863
## pHC -0.118 0.26554

Males (n=53)

## [1] "propcorrect"
##          r p-value
## aHC -0.165 0.09273
## pHC -0.011 0.90924
## [1] "patheff_acc_only"
##         r p-value
## aHC 0.166  0.0906
## pHC 0.020  0.8415

propcorrect

patheff (correct trials)

L/R/Mean Post/Ant Ratio + Propcorr or Patheff (n=96)

## [1] "propcorrect"
##                   r p-value
## Lpa_ratio    -0.164 0.00536
## Rpa_ratio    -0.264 0.00001
## meanpa_ratio -0.231 0.00008
## [1] "patheff_acc_only"
##                   r p-value
## Lpa_ratio    -0.071 0.22736
## Rpa_ratio    -0.034 0.56116
## meanpa_ratio -0.060 0.30951

propcorrect

Females (n=44)

## [1] "propcorrect"
##                   r p-value
## Lpa_ratio    -0.201 0.05558
## Rpa_ratio    -0.196 0.06278
## meanpa_ratio -0.216 0.03997
## [1] "patheff_acc_only"
##                   r p-value
## Lpa_ratio    -0.117 0.26832
## Rpa_ratio    -0.228 0.02993
## meanpa_ratio -0.183 0.08322

Males (n=52)

## [1] "propcorrect"
##                  r p-value
## Lpa_ratio    0.195 0.04669
## Rpa_ratio    0.062 0.52847
## meanpa_ratio 0.154 0.11796
## [1] "patheff_acc_only"
##                   r p-value
## Lpa_ratio    -0.166 0.09065
## Rpa_ratio    -0.063 0.52276
## meanpa_ratio -0.137 0.16241

propcorrect

patheff (correct trials)

No cut-off HR-T2 Subfield Volumes + Propcorr or Patheff (n=14)

propcorrect

	(Left) r	(Left) p	(Left) p_bonf	(Left) p_BH	(Right) r	(Right) p	(Right) p_bonf	(Right) p_BH
CA1	0.32	0.0402	0.5628	0.2742	0.25	0.1137	1.0000	0.2742
CA2/3	0.37	0.0189	0.2646	0.2646	-0.26	0.1060	1.0000	0.2742
DG	0.07	0.6506	1.0000	0.8280	0.27	0.0839	1.0000	0.2742
SUB	-0.22	0.1709	1.0000	0.3418	-0.01	0.9733	1.0000	0.9733
ERC	-0.11	0.5033	1.0000	0.7046	-0.06	0.7317	1.0000	0.8536
PRC	0.13	0.4358	1.0000	0.6779	-0.19	0.2426	1.0000	0.4246
PHC	-0.04	0.8022	1.0000	0.8639	-0.25	0.1175	1.0000	0.2742

patheff (correct trials)

	(Left) r	(Left) p	(Left) p_bonf	(Left) p_BH	(Right) r	(Right) p	(Right) p_bonf	(Right) p_BH
CA1	0.39	0.0108	0.1512	0.0504	0.42	0.0061	0.0854	0.0427
CA2/3	0.47	0.0020	0.0280	0.0280	0.28	0.0710	0.9940	0.1321
DG	0.28	0.0755	1.0000	0.1321	0.12	0.4531	1.0000	0.5767
SUB	0.17	0.2764	1.0000	0.3870	0.26	0.0957	1.0000	0.1489
ERC	0.10	0.5198	1.0000	0.5769	0.34	0.0308	0.4312	0.1078
PRC	-0.10	0.5357	1.0000	0.5769	0.01	0.9356	1.0000	0.9356
PHC	-0.29	0.0692	0.9688	0.1321	-0.31	0.0466	0.6524	0.1305

propcorrect

patheff (correct trials)

Females and Males

Females (n=6)

## [1] "propcorrect"
##       (Left) r p-value (Right) r p-value
## CA1     -0.150 0.66044     0.212 0.53194
## CA2/3    0.247 0.46348    -0.320 0.33716
## DG      -0.370 0.26314    -0.215 0.52465
## SUB     -0.029 0.93277     0.568 0.06809
## ERC     -0.292 0.38353    -0.446 0.16897
## PRC     -0.312 0.34984    -0.632 0.03679
## PHC     -0.503 0.11508    -0.816 0.00220
## [1] "patheff_acc_only"
##       (Left) r p-value (Right) r p-value
## CA1      0.234 0.48944     0.695 0.01771
## CA2/3    0.856 0.00078     0.103 0.76347
## DG      -0.025 0.94208     0.329 0.32247
## SUB     -0.173 0.61025    -0.094 0.78249
## ERC      0.102 0.76615     0.605 0.04858
## PRC     -0.228 0.50102     0.067 0.84478
## PHC     -0.845 0.00106    -0.255 0.44834

Males (n=8)

## [1] "propcorrect"
##       (Left) r p-value (Right) r p-value
## CA1      0.202 0.47070    -0.100 0.72248
## CA2/3   -0.007 0.98001    -0.676 0.00568
## DG      -0.266 0.33738     0.128 0.64998
## SUB     -0.519 0.04739    -0.327 0.23387
## ERC     -0.369 0.17619     0.183 0.51318
## PRC     -0.182 0.51522    -0.158 0.57394
## PHC      0.016 0.95493     0.282 0.30833
## [1] "patheff_acc_only"
##       (Left) r p-value (Right) r p-value
## CA1      0.582 0.02285     0.112 0.69011
## CA2/3    0.123 0.66308     0.376 0.16709
## DG       0.537 0.03918    -0.107 0.70556
## SUB      0.372 0.17247     0.593 0.01989
## ERC      0.026 0.92748     0.020 0.94237
## PRC     -0.214 0.44372    -0.111 0.69353
## PHC      0.059 0.83594    -0.317 0.25002

## Warning in max(ids, na.rm = TRUE): no non-missing arguments to max; returning
## -Inf

## Warning in max(ids, na.rm = TRUE): no non-missing arguments to max; returning
## -Inf

## Warning in max(ids, na.rm = TRUE): no non-missing arguments to max; returning
## -Inf

## Warning in max(ids, na.rm = TRUE): no non-missing arguments to max; returning
## -Inf

## Warning in max(ids, na.rm = TRUE): no non-missing arguments to max; returning
## -Inf

No cut-off HR-T2 Subfield Thickness + Propcorr or Patheff (n=26)

propcorrect

	(Left) r	(Left) p	(Left) p_bonf	(Left) p_BH	(Right) r	(Right) p	(Right) p_bonf	(Right) p_BH
CA1	0.01	0.9483	1.0000	0.9483	-0.04	0.7198	1.0000	0.8999
CA2/3	0.16	0.1760	1.0000	0.8213	-0.03	0.8280	1.0000	0.8999
DG	0.24	0.0385	0.5390	0.5390	0.16	0.1536	1.0000	0.8213
SUB	-0.06	0.6116	1.0000	0.8999	-0.03	0.8246	1.0000	0.8999
ERC	0.05	0.6856	1.0000	0.8999	0.08	0.4649	1.0000	0.8999
PRC	-0.08	0.4890	1.0000	0.8999	0.08	0.5167	1.0000	0.8999
PHC	0.08	0.4925	1.0000	0.8999	-0.02	0.8356	1.0000	0.8999

patheff (correct trials)

	(Left) r	(Left) p	(Left) p_bonf	(Left) p_BH	(Right) r	(Right) p	(Right) p_bonf	(Right) p_BH
CA1	-0.08	0.4631	1.0000	0.6608	-0.01	0.9596	1.0000	0.9596
CA2/3	0.23	0.0434	0.6076	0.1519	0.11	0.3567	1.0000	0.6242
DG	-0.16	0.1701	1.0000	0.3969	-0.02	0.8953	1.0000	0.9596
SUB	0.07	0.5192	1.0000	0.6608	0.11	0.3303	1.0000	0.6242
ERC	-0.27	0.0193	0.2702	0.1351	-0.20	0.0890	1.0000	0.2492
PRC	0.32	0.0046	0.0644	0.0644	-0.08	0.5111	1.0000	0.6608
PHC	-0.06	0.5800	1.0000	0.6767	-0.25	0.0314	0.4396	0.1465

Females and Males

Females (n=13)

## [1] "propcorrect"
##       (Left) r p-value (Right) r p-value
## CA1     -0.410 0.04177    -0.458 0.02126
## CA2/3    0.042 0.84191     0.042 0.84106
## DG       0.352 0.08459    -0.044 0.83305
## SUB     -0.136 0.51586    -0.280 0.17558
## ERC      0.017 0.93708    -0.100 0.63391
## PRC     -0.080 0.70364    -0.199 0.33931
## PHC      0.055 0.79570    -0.380 0.06085
## [1] "patheff_acc_only"
##       (Left) r p-value (Right) r p-value
## CA1      0.133 0.52739     0.205 0.32540
## CA2/3    0.393 0.05201     0.009 0.96566
## DG      -0.468 0.01828     0.140 0.50312
## SUB      0.146 0.48544     0.187 0.37103
## ERC     -0.439 0.02807    -0.184 0.37928
## PRC      0.476 0.01627     0.414 0.03985
## PHC      0.098 0.64117    -0.184 0.37865

Males (n=13)

## [1] "propcorrect"
##       (Left) r p-value (Right) r p-value
## CA1      0.200 0.33764     0.036 0.86298
## CA2/3   -0.201 0.33610    -0.379 0.06159
## DG      -0.243 0.24180     0.002 0.99338
## SUB     -0.183 0.38116    -0.045 0.83076
## ERC     -0.083 0.69331     0.220 0.28990
## PRC     -0.320 0.11915     0.019 0.92804
## PHC      0.029 0.88983     0.224 0.28256
## [1] "patheff_acc_only"
##       (Left) r p-value (Right) r p-value
## CA1     -0.256 0.21749    -0.222 0.28616
## CA2/3    0.194 0.35169     0.210 0.31342
## DG       0.171 0.41515    -0.128 0.54339
## SUB     -0.003 0.98745     0.062 0.76776
## ERC     -0.135 0.51852    -0.203 0.33057
## PRC      0.023 0.91246    -0.334 0.10316
## PHC     -0.181 0.38556    -0.303 0.14064

propcorrect (n=26, thickness)

path eff for correct trials (n=26, thickness)

HR-T2 Body-only Subfield Volumes + Propcorr or Patheff (n=17)

[Not analyzed in manuscript]

HR-T2 Body-only Subfield Thickness + Propcorr or Patheff (n=17)

[Not analyzed in manuscript]

Full Reg-T2 Subfield Volumes + Propcorr or Patheff (n=26)

propcorrect

	(Left) r	(Left) p	(Left) p_bonf	(Left) p_BH	(Right) r	(Right) p	(Right) p_bonf	(Right) p_BH
aHC	0.24	0.0388	0.3880	0.3880	0.04	0.7331	1.0000	0.8146
pHC	0.02	0.8751	1.0000	0.8751	0.10	0.3942	1.0000	0.7195
ERC	-0.11	0.3378	1.0000	0.7195	-0.07	0.5195	1.0000	0.7195
PRC	-0.06	0.5756	1.0000	0.7195	-0.16	0.1764	1.0000	0.5880
PHC	-0.07	0.5346	1.0000	0.7195	0.18	0.1140	1.0000	0.5700

patheff (correct trials)

	(Left) r	(Left) p	(Left) p_bonf	(Left) p_BH	(Right) r	(Right) p	(Right) p_bonf	(Right) p_BH
aHC	0.17	0.1316	1.0000	0.2193	0.19	0.0913	0.9130	0.1836
pHC	-0.12	0.3053	1.0000	0.3392	0.07	0.5635	1.0000	0.5635
ERC	-0.14	0.2316	1.0000	0.2895	-0.37	0.0010	0.0100	0.0100
PRC	0.14	0.2180	1.0000	0.2895	0.19	0.0918	0.9180	0.1836
PHC	-0.33	0.0035	0.0350	0.0175	-0.27	0.0163	0.1630	0.0543

patheff (correct trials)

Full Reg-T2 Subfield Thickness + Propcorr or Patheff (n=26)

propcorrect

	(Left) r	(Left) p	(Left) p_bonf	(Left) p_BH	(Right) r	(Right) p	(Right) p_bonf	(Right) p_BH
aHC	0.05	0.6568	1.0000	0.8313	-0.02	0.8313	1.0000	0.8313
pHC	-0.08	0.4931	1.0000	0.8313	-0.03	0.7835	1.0000	0.8313
ERC	-0.12	0.3169	1.0000	0.8313	-0.08	0.4968	1.0000	0.8313
PRC	-0.03	0.7839	1.0000	0.8313	-0.19	0.0951	0.9510	0.4755
PHC	-0.27	0.0158	0.1580	0.1580	-0.03	0.7863	1.0000	0.8313

patheff (correct trials)

	(Left) r	(Left) p	(Left) p_bonf	(Left) p_BH	(Right) r	(Right) p	(Right) p_bonf	(Right) p_BH
aHC	0.18	0.1204	1.0000	0.2361	0.23	0.0428	0.4280	0.2140
pHC	0.06	0.5843	1.0000	0.5843	0.16	0.1653	1.0000	0.2361
ERC	-0.17	0.1478	1.0000	0.2361	-0.37	0.0008	0.0080	0.0080
PRC	-0.14	0.2352	1.0000	0.2940	0.09	0.4407	1.0000	0.4897
PHC	-0.17	0.1462	1.0000	0.2361	-0.20	0.0837	0.8370	0.2361

patheff (correct trials)